5470-70-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5470-70-2 as follows.
A solution of methyl 6-.methylnicolinate (15 g, 9934 n:imoi) and m-CPBA (18,8 g, 109.3mmol) in DCM (100 rnL) was stirred at room temperature for 4 hours. The reaction mixture wasquenched with 200 mL of saturated aqueous Na2SO3 and 100 mL of saturated aqueous NaHCO3. The resulting mixture was extracted with EA (20() mLx3), The combined EA layer was washed with brine and dried over Na2SO4. Filtered and the filtrate was concentrated. The residue was purified by colunm chromatography on silica gel (PE/EtOAc = 5/i) to afford 5-(methoxycarbonyi)-2-methylpyridine 1-oxide as a solid. MS-ESI (m/z): 168.2 (M+1) (LC-MSmethod 1); Ret. time: 0.32 mm).
The chemical industry reduces the impact on the environment during synthesis 5470-70-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph A.; BOGA, Sobhana Babu; GAO, Xiaolei; GUIADEEN, Deodialsingh; CAI, Jiaqiang; LIU, Shilan; WANG, Dahai; WU, Hao; YANG, Chundao; (261 pag.)WO2016/106628; (2016); A1;,
Pyridine – Wikipedia,
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