The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98-98-6, name is Picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. 98-98-6
[00091] 4-Chloropicolinic acid methyl ester (CYD-1-1). A mixture of picolinic acid (10.0 g, 81.0 mmol, 1 equiv.) and sodium bromide (16.7 g, 162.0 mmol, 2 equiv.) in thionyl chloride (41 mL) was refluxed for 5 h at 80C. After that, the solvent was removed under the vacuum at 85C to afford the brown residue. 80 mL of anhydrous methanol was slowly added into the residue and the mixture was stirred at room temperature for half an hour. The solvent was evaporated, and the residue was taken up in the saturated sodium bicarbonate and extracted with ethyl acetate (three times). The organic layers were combined, washed with saturated brine, dried over anhydrous Na2S04 and evaporated. The residue was purified by silica gel column; eluting with 33% EtOAc in hexane afforded 4-chloropicolinic acid methyl ester (CYD-1-1) (8.0 g, 64%) as a brown solid; silica gel TLC Rf = 0.15 (1 :3 EtOAc/hexane); mp 55-56C; 1H NMR (600 MHz, CDC13) delta 8.67 (d, 1H, J = 4.8 Hz), 8.16 (d, 1H, J = 1.8 Hz), 7.51 (m, 1H), 4.04 (s, 3H).
Statistics shows that 98-98-6 is playing an increasingly important role. we look forward to future research findings about Picolinic acid.
Reference:
Patent; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHOU, Jia; DING, Chunyong; CUNNINGHAM, Kathryn, A.; WO2013/86266; (2013); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem