An article Generation of a Heteropolycyclic and sp(3)-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels-Alder and ROM-RCM Reaction Sequence WOS:000458273900021 published article about DIVERSITY-ORIENTED SYNTHESIS; CHEMICAL SPACE; CYCLIZATION; ACID; DRUG; METATHESIS; COMPLEXITY; MITSUNOBU; ESTERS in [Flagstad, Thomas; Azevedo, Carlos M. G.; Troelsen, Nikolaj S.] Tech Univ Denmark, Dept Chem, Ctr Nanomed & Theranost, Kemitorvet 207, DK-2800 Lyngby, Denmark; EDELRIS, 115 Ave Lacassagne, F-69003 Lyon, France; Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 637551, Singapore; Univ Copenhagen, Dept Immunol & Microbiol, Costerton Biofilm Ctr, DK-2200 Copenhagen, Denmark in 2019.0, Cited 43.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 500-22-1
Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A-C) from a single precursor, which in turn is available through a one-pot Petasis 3-component reaction/Diels-Alder cascade reaction. We demonstrate the versatility of the approach through the synthesis of 35 exemplary compounds from the three classes, as well as by the production of 2188 final compounds, which have been included in the Joint European Compound Library of the European Lead Factory.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem