An article A novel cluster of C-5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold WOS:000481805000030 published article about CIRCULAR-DICHROISM; CURCUMIN; ANTITUMOR; TOXICITY; ANALOGS; 3,5-BIS(ARYLIDENE)-4-PIPERIDONES; CYTOTOXICITY; APOPTOSIS; DELIVERY; CELLS in [Huber, Imre; Perjesi, Pal] Univ Pecs, Dept Pharmaceut Chem, H-7624 Pecs, Hungary; [Zupko, Istvan; Gyovai, Andras] Univ Szeged, Dept Pharmacodynam & Biopharm, H-6720 Szeged, Hungary; [Horvath, Peter; Kiss, Eszter] Semmelweis Univ, Dept Pharmaceut Chem, H-1092 Budapest, Hungary; [Gulyas-Fekete, Gergely; Schmidt, Janos] Univ Pecs, Dept Biochem & Med Chem, H-7624 Pecs, Hungary in 2019.0, Cited 50.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1
A new series (6) of C-5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is described here with their evaluation for in vitro antiproliferative activities. Evaluation of 31 compounds against human A2780 (ovarian), C33A (cervix) and MDA-MB-231 (breast) cancer cell lines was performed to obtain structure activity relation data. The best performer was (2E,6E)-2,6-bis(3 ‘-nitrobenzylidene)-4-hydroxycyclohexanone (6h) with IC50 values of 0.68 mu M (A2780), 0.69 mu M (C33A) and 0.92 mu M (MDA-MB-231) compared to cisplatin with 1.30 mu M, 3.69 mu M and 19.13 mu M, respectively. According to calculated physicochemical properties some members in series 6, namely (2E,6E)-2,6-bis[(4 ‘-pyridinyl)methylene]-4-hydroxycyclohexanone (6p) [IC50 = 0.76 mu M (A2780), 2.69 mu M (C33A), 1.28 mu M (MDA-MB-231)] seem to have improved bioavailability compared to curcumin. Selected members of series 6 were involved in circular dichroism spectroscopic measurements in order to determine their interaction with natural DNA. Based on these data, we conclude that these derivatives do not bind to DNA in vitro. A proposal is summarized based on mass spectrometric assessment for fingerprint analysis in biological research of such C-5-curcuminoids.
Quality Control of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Huber, I; Zupko, I; Gyovai, A; Horvath, P; Kiss, E; Gulyas-Fekete, G; Schmidt, J; Perjesi, P or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem