98-98-6 , The common heterocyclic compound, 98-98-6, name is Picolinic acid, molecular formula is C6H5NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Picolinic acid (20.0 mmol) and 1,2-diaminobenzene (20.0 mmol) were added to 28 g PPA (polyphosphric acid),and stirred at 160 C for 8 h. The resulting viscous solution was poured into 500 mL water, producing a solid which was collected by suction filtration. The solid was suspended in 500 mL of aqueous 0.5 M Na2CO3, and filtered giving a pale yellow powder. Recrystallization from methanol/water. Yield: 43%, m.p.: 219 C, chemical formula (mol.wt.): C12H9N3 (195.22 g/mol), elemental analysis, calc. (%): C, 73.83; H, 4.65; N, 21.52, found: C, 73.75; H, 4.54; N, 21.43, 1H NMR: 8.213 (d, 2H, H4′,5′ ), 8.169 (d, 1H, H6” ), 7.964 (dt, 1H, H4” ), 7.737 (d, 1H, H3” ), 7.699-7.592 (complex, 4H, H 3′,6′,1,5” ), 13C NMR: 159.36 (C2” ), 156.91 (C2), 146.76 (C6” ), 137.35 (C2′ ), 133.22 (C1′ ), 130.54 (C4” ), 129.50 (C5′ ), 129.09 (C4′ ), 128.55 (C3” ), 128.30 (C3′), 127.41 (C6′ ), 117.44 (C5” ), FT-IR (KBr, cm-1): nu(NH), 3399 (s); nu(C-H), 3055 (m); nu(C=C), 1545 (s); nu(C=N), 1532 (s); delta(C-H), 741 (s).
According to the analysis of related databases, 98-98-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Patel, Mohan N.; Dosi, Promise A.; Bhatt, Bhupesh S.; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 86; (2012); p. 508 – 514;,
Pyridine – Wikipedia,
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