5350-93-6, Adding a certain compound to certain chemical reactions, such as: 5350-93-6, 6-Chloropyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5350-93-6, blongs to pyridine-derivatives compound.
Step a: (6-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester To a mixture of 6-chloropyridin-3-amine (30.0 g, 0.23 mol), DMAP (1 g) and Et3N (41.7 g, 0.47 mol) in CH2Cl2 (200 mL) was added Boc2O (54.5 g, 0.25 mol) at 0 C. The mixture was allowed to warm to room temperature and stirred overnight. The mixture was washed with saturated NaHCO3 solution. The aqueous solution was extracted with dichloromethane. The combined organics were washed with brine (100 mL), dried over Na2SO4 and evaporated under vacuum to give tert-butyl 6-chloropyridin-3-ylcarbamate (50.0 g, 94%), which was used directly in the next reaction. 1H NMR (300 MHz, CDCl3) delta 8.23 (d, J=2.7 Hz, 1H), 7.97 (d, J=6.9 Hz, 1H), 7.27-7.24 (m, 1H), 6.58 (s, 1H), 1.52 (s, 9H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5350-93-6, its application will become more common.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; US2009/253736; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem