69045-84-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a suspension of NaH (0.043 g, 1.8 mmol, 4 equiv) in anhyd THF (2mL) at 0 C was added dropwise a solution of ethyl 6-methyl-7-oxo-2,3-dihydro-1H-pyrazolo[1,5-a]pyrimidin-1-ium-5-carboxylate 2,2,2-trifluoroacetate (38; 0.15 g, 0.44 mmol) in DMF (0.5 mL). After stirring the reaction mixture for 10 min, 2,3-dichloro-5-(trifluoromethyl)pyridine (0.115 g, 0.53 mmol, 1.2 equiv) was added dropwise, followed by the addition of THF (6 mL) and DMF (1.5 mL). The reaction mass was stirred for 1 h at r.t., then acidified with aq 2 N HCl, and extracted with EtOAc (3 ¡Á 50 mL). The combined organic layers were washed with brine, dried (Na2SO4), and concentrated under reduced pressure to obtain a crude mass. Trituration with Et2O and cooling to0 C afforded the desired product 39 as an off-white solid; yield: 0.135g (81%); mp 185-187 C.IR (KBr): 2922, 1734, 1672, 1554, 1323, 1136, 1051 cm-1.1H NMR (400 MHz, DMSO-d6): delta = 2.04 (s, 3 H), 3.20-3.44 (m, 8 H),4.16 (br t, J = 7.40 Hz, 2 H), 8.58-8.61 (m, 1 H), 8.65 (s, 1 H), 13.39-13.88 (m, 1 H).13C NMR (100 MHz, DMSO-d6): delta = 166.5, 157.7, 156.9, 156.2, 149.7,142.5, 136.5, 123.8, 123.0, 122.7, 121.4, 121.1, 119.9, 51.3, 30.3, 11.1. HRMS-ESI: m/z calcd for C14H10ClF3N4O3 (M + H): 375.0472; found:375.0465.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine.
Reference:
Article; Shirsale, Ashwini; Patil, Yogesh; Rawal, Girish K.; Pabba, Jagadish; Berthon, Guillaume; Sonawane, Ravindra P.; Sikervar, Vikas; Synthesis; vol. 50; 10; (2018); p. 2087 – 2093;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem