585-48-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 585-48-8, name is 2,6-Di-tert-butylpyridine, molecular formula is C13H21N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 16 1-(1-Naphthoyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S,R)-(ethoxymethyl)pyrrolidine To a solution of 0.033 g (0.074 mmol) of 1-(1-naphthoyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(SR)-hydroxymethylpyrrolidine and 0.057 g (0.22 mmol) of AgOTf in 2 mL of CH2Cl2 was added 0.058 mL (0.26 mmol) of 2,6-di-t-butylpyridine and 0.019 mL (0.24 mmol) of ethyl iodide and the reaction mixture was stirred at rt for 1.5 h. The reaction mixture was diluted with CH2Cl2 and filtered through a thin pad of Celite eluding with acetone:hexanes (1:2). The filtrate was concentrated and the residue was purified by chromatography (silica, acetone:hexanes, 1:3 to 1:2) to give the title compound. 1H NMR (CDCl3) delta (key peaks) 7.88-7.91 (M, 3H), 7.47-7.57 (M, 4H), 7.09-7.12 and 7.18-7.21 (M, 2H, 7.01 and 6.96 (t, 2H, J=8.5 Hz), 1.25 and 1.09 (t, 3H, J=7.0 Hz); Mass Spectrum (ESI) m/e=475 (M+1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 585-48-8, 2,6-Di-tert-butylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Merck & Co., Inc.; US6372764; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem