13472-85-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13472-85-0, name is 5-Bromo-2-methoxypyridine, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-Bromo-2-methoxypyridine (28.8 g, 150 mmol, 1 eq.) Was dissolved in 300 ml of anhydrous tetrahydrofuran and set aside.Diisopropylamine (17g, 165mmol, 1.1eq.) Was dissolved in 150ml of anhydrous tetrahydrofuran, cooled to -5C , under nitrogen,N-Butyllithium (66 ml, 165 mmol, 1.1 eq.) Was added dropwise to the above solution.After the dropwise addition, the mixture was stirred for 30 minutes.Reduce the temperature of the above reaction system to -78C ,A solution of 5-bromo-2-methoxypyridine in tetrahydrofuran was added dropwise.After the dropwise addition, the mixture was stirred for 1 hour.Then, N, N-dimethylformamide (16.8 g, 225 mmol, 1.5 eq.) Was added dropwise to the above reaction system, and reacted for 2 hours.After the reaction was completed, 150 ml of ammonium chloride solution was slowly added to the reaction solution.After extraction with n-hexane, the organic phase was dried over anhydrous sodium sulfate and concentrated.The resulting concentrate was slurried with n-hexane and filtered with suction,The filter cake was dried to obtain 25 g of white solid 5-bromo-2-methoxypyridine-4-carbaldehyde,The yield is 77%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13472-85-0, 5-Bromo-2-methoxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Ali Biological New Materials (Changzhou) Co., Ltd.; Shi Jianyun; Xu Yibo; Dai Hongsheng; Zhou Chao; (8 pag.)CN110734397; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem