Extended knowledge of 5-Iodo-3-methylpyridin-2-amine

With the rapid development of chemical substances, we look forward to future research findings about 166266-19-9.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 166266-19-9, name is 5-Iodo-3-methylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H7IN2

Example 2 Preparation of 2-chloro-3-methyl-5-iodopyridine At -10 C., 21.3 g of chlorine gas were introduced into a suspension of 146 g of 10% strength by weight hydrochloric acid and 23.4 g of 2-amino-3-methyl-5-iodopyridine [J. Org. Chem. (1995), p. 5356]. At about -50 C., a solution of 48.3 g of sodium nitrite in 120 ml of water was subsequently added dropwise. After about 2 hours of stirring at 0 C., the mixture was diluted with 1 l of water and extracted with methyl tert-butyl ether (MtBE). The organic phases were washed with NaHCO3 solution and water and then dried. Distillative removal of the solvent under reduced pressure and silica gel chromatography (cyclohexane/MtBE=1:10) gave 3.6 g of the product in the form of dark crystals. 1H-NMR (CDCl3, ppm): delta=8.4 (1H); 7.9 (1H); 2.3 (3H).

With the rapid development of chemical substances, we look forward to future research findings about 166266-19-9.

Reference:
Patent; BASF Aktiengesellschaft; US6372766; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem