Electric Literature of 896139-85-8, Adding some certain compound to certain chemical reactions, such as: 896139-85-8, name is Imidazo[1,2-a]pyridin-7-ol,molecular formula is C7H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 896139-85-8.
To a solution ofimidazo[l,2-a]pyridin-7-ol (CAS 896139-85-8; 128 mg, 0.955 mmol) in dryNMP (2 mL) is added CS2CO3 (311 mg, 0.955 mmol). The reaction mixture is degassed with N2 for 5 min and stirred at RT for 45 min. Copper(I) chloride (CAS 7758-89-6; 10 mg, 0.10 mmol) and bromobenzene (CAS 108-86-1 ; 100 mg, 0.64 mmol) are added and the mixture is stirred at 160 C for 3 h under microwave irradiation. Copper (I) chloride (10 mg, 0.10 mmol) is added and the reaction mixture is heated at 160 C for 1 h under microwave irradiation. Imidazo[l,2-a]pyridin-7-ol (86 mg, 0.64 mmol) is added and the reaction mixture is heated at 160 C for 1 h under microwave irradiation. The reaction medium is quenched with a water and sat. aq. NaFtCC solution mixture and extracted with EtOAc. The organic layers are combined, dried over Na2S04, filtered and concentrated. Traces of NMP are removed under nitrogen flush to afford Int 17 that is used as such.
According to the analysis of related databases, 896139-85-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GALAPAGOS NV; DESROY, Nicolas; JONCOUR, Agnes, Marie; PEIXOTO, Christophe; TEMAL-LAIB, Taoues; TIRERA, Amynata; BUCHER, Denis; AMANTINI, David; DE VOS, Steve, Irma, Joel; BRYS, Reginald, Christophe, Xavier; (396 pag.)WO2019/238424; (2019); A1;,
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