Adding a certain compound to certain chemical reactions, such as: 65515-39-1, 2-Methoxy-4,6-dimethylnicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H10N2O, blongs to pyridine-derivatives compound. COA of Formula: C9H10N2O
Example 8: (2-Methoxy-4,6-dimethylpyridin-3-yl)methanamine To a slurry solution of aluminum (III) lithium hydride (234 mg, 6.17 mmol) in diethyl ether (2 ml_) was added a saturated solution of 2-methoxy-4,6- dimethylnicotinonitrile (500 mg, 3.08 mmol) in ether (5 ml_) and stirred at room temperature for 1 h. After completion of the reaction, minimum amount of water was carefully added and the crude product obtained was extracted with hot benzene / toluene and concentrated. Resulting oily compound was distilled at 0.5 mm vacuum at 95-100 SC to obtain the title compound. Yield: 300 mg (58.66 %); 1H NMR (DMSO-d6, 300 MHz): delta 6.53 (s, 1 H), 3.92 (s, 3H), 3.76 (s, 2H), 2.36 (s, 3H), 2.27 (s, 3H); MS (ESI+): m/z 166.9 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,65515-39-1, 2-Methoxy-4,6-dimethylnicotinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; GUPTE, Amol; ROYCHOWDHURY, Abhijit; JADHAV, Ravindra, Dnyandev; KANDRE, Shivaji, Sadashiv; KADAM, Kishorkumar, Shivajirao; CHAVAN, Sambhaji; GADEKAR, Pradip, Keshavrao; GUHA, Tandra; WO2014/155301; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem