624-28-2 , The common heterocyclic compound, 624-28-2, name is 2,5-Dibromopyridine, molecular formula is C5H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 1: 5-Bro -2-methoxypyridine A mixture of 2,5-dibromopyridine (5.5 g, 23.2 mmol) and NaOMe (3.76 g, 69.6 mmol) in MeOH (60 mL) was heated at 70C for 1 hour and then allowed to cool to room temperature. The reaction mixture was diluted with water (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic layers were dried over Na2S04 and concentrated under reduced pressure to give a pale yellow volatile oil (2.5 g, 58% yield). 1H NMR (400 MHz, DMSO-d6): delta 8.26 (s, 1H), 7.87 (dd, 1H), 6.81 (d, 1H), 3.82 (s, 3H).
The synthetic route of 624-28-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ENDO PHARMACEUTICALS INC.; SMITH, Roger, Astbury; KETHIRI, Raghava, Reddy; KRISTAM, Rajendra; LAPING, Nicholas, James; VENKATESHAPPA, Chandregowda; KULKARNI, Bheemashankar; DEVRAJ, Rajesh; DEWANG, Purushottam; WO2013/49559; (2013); A1;,
Pyridine – Wikipedia,
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