In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 886371-28-4, name is 3-Bromo-6-chloroimidazo[1,2-a]pyridine, the common compound, a new synthetic route is introduced below. COA of Formula: C7H4BrClN2
General procedure: To an oven-dried 5 mL microwave vessel was addedPd(dppf)Cl2·CH2Cl2 (4 mol%), aryl halide/pseudohalide (1equiv.), organoboron (1 equiv.), and K3PO4 (3 equiv.). The vesselwas then capped and purged with N2 before addition of DMI (1mL, 0.25 M) and H2O (5 equiv.). The reaction mixture washeated to 60 C and maintained at this temperature with stirringfor 1 h before the vessel was vented and decapped. Thesolution was then diluted with EtOAc (10 mL) and washed withwater (2 × 20 mL) and brine (2 × 20 mL). The organics were thenpassed through a hydrophobic frit and concentrated underreduced pressure to give a residue, which was purified by flashchromatography (silica gel) to afford the product.
The synthetic route of 886371-28-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wilson, Kirsty L.; Murray, Jane; Sneddon, Helen F.; Jamieson, Craig; Watson, Allan J. B.; Synlett; vol. 29; 17; (2018); p. 2293 – 2297;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem