Application of 52605-96-6 ,Some common heterocyclic compound, 52605-96-6, molecular formula is C6H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Chloro-3-methoxypyridine (1.22 g, 8.46 mmol) was dissolved in hydrazine hydrate (1 : 1) (10 ml) and stirred at reflux for 4 h. The reaction mixture was cooled to room temperature and evaporated. The residue was retaken in 10% methanol in chloroform and washed with an aqueous potassium carbonate solution. The aqueous phase was extracted with 10% methanol in chloroform . The combined organic layers were dried over magnesium sulfate and evaporated affording 781 mg (59% of th.) of the title compound. LC-MS (Method 6): Rt = 0.76 min; MS (ESIpos): m/z = 140 [M+H]+-NMR (400 MHz, DMSO-d6) delta [ppm] : 7.65 (dd, 1H), 7.09-6.87 (m, 2H), 6.56 (dd, 1H), 4.37- 3.85 (br. s, 2H), 3.76 (s, 3H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52605-96-6, 2-Chloro-3-methoxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; TINEL, Hanna; SCHMECK, Carsten; WASNAIRE, Pierre; SCHIRMER, Heiko; LUSTIG, Klemens; (131 pag.)WO2019/81306; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem