Electric Literature of 1227594-89-9, Adding some certain compound to certain chemical reactions, such as: 1227594-89-9, name is 3-Fluoro-4-(trifluoromethyl)pyridin-2(1H)-one,molecular formula is C6H3F4NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1227594-89-9.
[00778] Step C: A solution of triphenylphosphine (39 mg, 0.149 mmol) in THF (1 mL) at room temperature was treated with DIAD (29 muL, 0.149 mmol). The mixture was stirred for 10 min and then tert-butyl (3-(1-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-pyrazol-4-yl)-1-((1r,4S)-4-hydroxycyclohexyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)carbamate (50.9 mg, 0.099 mmol) was added in THF (1 mL), followed by 3-fluoro-4-(trifluoromethyl)pyridin-2-ol (36 mg, 0.199 mmol). The mixture stirred overnight and partitioned between water (15 mL) and EtOAc (10 mL). The aqueous layer was extracted with EtOAc (2 x 10 mL). The combined organic phases were washed with brine (30 mL), dried over Na2SO4, filtered and concentrated. The residue was purified over silca gel (20-70% EtOAc in hexanes) to afford tert-butyl (3-(1-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-pyrazol-4-yl)-1-((1s,4R)-4-((3-fluoro-4-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)carbamate (77.7 mg, 115% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1227594-89-9, 3-Fluoro-4-(trifluoromethyl)pyridin-2(1H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; BOYS, Mark Laurence; COOK, Adam; GAUDINO, John; HINKLIN, Ronald Jay; LAIRD, Ellen; MCNULTY, Oren T.; METCALF, Andrew T.; NEWHOUSE, Brad; ROBINSON, John E.; (545 pag.)WO2019/113190; (2019); A1;,
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