Reference of 84539-34-4 ,Some common heterocyclic compound, 84539-34-4, molecular formula is C5H4Br2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 77: 3-(benzenesuIfoiiyl)-7-bromo-1H-pyrrolo[3, 2-cjpyridin- 2-amine To a stirred and nitrogen degassed solution of 3,5-dibromopynchn-4-amine (CM 84539-34-4; 2.5 g, 9.92 mmol), tetrakis(triphenylphosphane) palladium (287 mg, 248 itmol) in anhydrous DME (20 mL) was added a solution of 2- (benzenesulfonyl)acetonitrile (CM 7605-25-9; 1.98 g, 10.92 nimol) and sodium hydride (992 mg, 24.81 mmol, 6o% dispersion in oil) in anhydrous DME (12 mL). The reaction mixture was heated under microwave irradiation at 130 C for 2 h. The reaction mixture was poured into water and extracted with EtOAc. The combined organics were filtered and dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by column chromatography (silica, o-ioo% EtOAc / petroleum ether) to afford the title compound.?H NMR (400 MHz, DMSO-d6) 6 ppm 6.6 (br. s., 2 H) 7.40 – 7.64 (m, 3 H) 7.91 – 7.98 (m, 2 H) 8.i8 (s, 1 H) 8.54 (hr. s., 1 H) 11.57 (s, 1 H).MS ESi 354
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,84539-34-4, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA CAMBRIDGE LTD; BARKER, Gregory; DAVENPORT, Richard; DOWNHAM, Robert; FARNABY, William; GOLDBY, Anne; HANNAH, Duncan; HARRISON, David; WILLEMS, Henriette; (390 pag.)WO2015/198045; (2015); A1;,
Pyridine – Wikipedia,
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