109-04-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-04-6, name is 2-Bromopyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a 250 mL two-neck flask was added 2-bromopyridine (5.00 g, 31.7 mmol), and the mixture was stirred under a nitrogen atmosphere for 5 minutes, and then anhydrous tetrahydrofuran (150 mL) was further added. Next, the reaction flask was maintained at 78C using a dry ice/acetone bath, and n-butyllithium (14.0 mL; 2.5 M in n-hexane) was slowly added dropwise.After completion of the dropwise addition, the mixture was stirred at this temperature for 1 hour, and tributyltin chloride (10.3 mL, 38.0 mmol) was slowly added dropwise.The reaction was then allowed to slowly return to room temperature. After stirring for 12 hours, an appropriate amount of a saturated aqueous solution of ammonium chloride was added and the mixture was extracted with ethyl acetate.The combined organic layers were washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was drained to give the tin-synthesized 2-(tributylstannyl)pyridine, which was not purified.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 109-04-6, 2-Bromopyridine.
Reference:
Patent; NATIONAL TSING HUA UNIVERSITY; CHI, YUN; PALANISAMY, RAJAKANNU; MEGANATHAN, NANDAKUMAR; (65 pag.)TWI586662; (2017); B;,
Pyridine – Wikipedia,
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