Related Products of 889944-76-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 889944-76-7, name is 6-Chloro-4-methylpyridine-3-sulfonyl chloride. A new synthetic method of this compound is introduced below.
A mixture of 6-chioro-4-methyipyridine-3-sulfonyl chloride (0.25 g, 1.106 mmol) in THF (5 mL) was treated with Hunig’s Base (0.290 mL, 1.659 mmol), followed by dimethylamine (2.0 M in THF, 0.829 mL, 1.659 mmol) at room temperature. After 1 hour, the reaction was concentrated and the crude was purified by column chromatography (24g Si02, 0 to 100% EtO Ax-hexanes, gradient elution) to afford 6- chloro-N,N,4-trimethylpyridine-3-sulfonamide (213 mg, 0.908 mmol, 82 % yield). LCMS(M+H) = 234.9; LCMS RT = 0.79 min; (Column: BEH Cl 8 2.1 x 50mm; Mobile Phase A: water with 0.05% TFA; Mobile Phase B: acetonitrile with 0.05% TFA; Temperature: 50 C; Gradient: 2-98% B over 1.7 min; Flow: 0.8 mL/min).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,889944-76-7, 6-Chloro-4-methylpyridine-3-sulfonyl chloride, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; TARBY, Christine M.; NORRIS, Derek J.; LO, Julian C.; AHUJA, Vijay T.; SEITZ, Steven P.; GAVAI, Ashvinikumar V.; TOKARSKI, John S.; RAJASAGI, Mohini; WICHROSKI, Michael; BROEKEMA, Matthias; (155 pag.)WO2019/213340; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem