Application of 40473-07-2 ,Some common heterocyclic compound, 40473-07-2, molecular formula is C6H6BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: The aryl halide was dissolved in 5mL of methanol per mmol of (hetero)arylhalide, magnesium (5 equiv.) added and the mixture was stirred at room temperature. After completion of the reaction (between 6-12h), the reaction mixture was poured into water, acidified with dilute HCl, and extracted with ethyl acetate. The organic phase was dried over MgSO4 and concentrated under reduced pressure. The product was purified if necessary by column chromatography on silica gel.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 40473-07-2, 2-Bromo-6-methoxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Jouha, Jabrane; Khouili, Mostafa; Hiebel, Marie-Aude; Guillaumet, Gerald; Suzenet, Franck; Tetrahedron Letters; vol. 59; 32; (2018); p. 3108 – 3111;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem