Synthetic Route of 896139-85-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 896139-85-8, name is Imidazo[1,2-a]pyridin-7-ol. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of imidazo[l,2-a]pyridin-7-ol (CAS 896139-85-8; 35 mg, 0.26 mmol) in dry DMF (3 mL) is added NaH (60% in mineral oil, 42 mg, 1.04 mmol) and the mixture is stirred at RT for 10 min. Methyl l-bromocyclopentane-l-carboxylate (CAS 51572-54-4; 143 pL, 1.04 mmol) is added and the mixture is heated at 50 C for 20 h. The reaction mixture is concentrated and the residue is diluted with water and DCM. The aqueous phase is extracted with DCM. Organic layers are combined, dried over Na2S04, filtered and concentrated to afford the expected compound. LCMS: MW (calcd): 260.3; m/z MW (obsd): 261.6 (M+H)
According to the analysis of related databases, 896139-85-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GALAPAGOS NV; DESROY, Nicolas; JONCOUR, Agnes, Marie; PEIXOTO, Christophe; TEMAL-LAIB, Taoues; TIRERA, Amynata; BUCHER, Denis; AMANTINI, David; DE VOS, Steve, Irma, Joel; BRYS, Reginald, Christophe, Xavier; (396 pag.)WO2019/238424; (2019); A1;,
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