Related Products of 55404-31-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55404-31-4, name is 3-Bromo-2-chloro-4-methylpyridine. A new synthetic method of this compound is introduced below.
Example 193; Synthesis of 3-bromo-4-methylpyridin-2(1H)-one; To a resealable pressure vessel charged with 3-bromo-2-chloro-4-picoline (1.200 g, 5.81 mmol) was added formic acid (13.1 ml, 348 mmol) and water (4.00 ml, 222 mmol). The tube was sealed and the solution heated to 1200C. After 72 hrs, the solution was cooled to RT and concentrated in vacuo. The residue was purified by reverse phase chromatography (neutral) to afford 3-bromo-4- methylpyridin-2(1H)-one as a white solid. M+H+ = 188.0.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55404-31-4, 3-Bromo-2-chloro-4-methylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; AMGEN INC.; WO2008/11109; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem