Application of 16744-81-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.16744-81-3, name is 4-Methoxypicolinaldehyde, molecular formula is C7H7NO2, molecular weight is 137.14, as common compound, the synthetic route is as follows.
A mixture of 45 G of 4-METHOXYPYRIDINE-2-CARBALDEHYDE (Ashimori et AL., Chem. Pharm. Bull. 38, 2446- 2458 (1990) ), 75.80 G of pyridine hydrochloride, 102.45 G of monomethyl malonate potassium salt and 4.1 mi of piperidin in 700 ML of pyridine are slowly heated, with stirring, to 120 C. When the evolution of gas starts, the heating source is temporarily removed to stop the reaction from becoming too violent. Once the reaction has subsided, the mixture is stirred at 120 C for a further 2.5 h, and the pyridine is then distilled off under reduced pressure. The residue is partitioned between ethyl acetate/water and the organic phase is washed with water and dried. The residue obtained after concentration is chroma- tographed on a silica gel column using ethyl ACETATE/PETROLEUM ether 2: 1. This initially gives 43.2 G of the title compound as a yellow oil which crystallizes on standing and then shows a m. p. of 80-82 C. The mass spectrum shows the molecular peak MHD AT 194 DA.
Statistics shows that 16744-81-3 is playing an increasingly important role. we look forward to future research findings about 4-Methoxypicolinaldehyde.
Reference:
Patent; ALTANA PHARMA AG; WO2004/76451; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem