504-29-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.
S1. Dichloromethane (900 g) was added to a 2 L three-neck bottle at room temperature. 2-Aminopyridine (135 g, 1.0 eq), triethylamine (174 g, 1.2 eq), Cool down to 10-20 C, add pivaloyl chloride (189 g, 1.1 eq), After the addition is completed, the system is warmed to 20-25 C, and the reaction is 2-3 h; After the reaction was completed, water was added to the reaction system, and after stirring for 0.5 h, the organic phase was separated. The aqueous phase was extracted with dichloromethane (500 g). Add petroleum ether (800g) directly at 0 C, stir for 2 h, suction filtration, 2-Pentylaminopyridine was obtained in a yield of 83%.
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Reference:
Patent; Aisite (Chengdu) Bio-pharmaceutical Co., Ltd.; Luo Jianye; Li Hongqiang; Guo Peng; (10 pag.)CN108675954; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem