Application of 56946-65-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56946-65-7, name is 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[b]pyridine, molecular formula is C8H7Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[Step 1] Production of 2,4-dichloro-6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide To a solution of 2,4-dichloro-6,7-dihydro-5H-cyclopenta[b]pyridine (1 g) in CH2Cl2 (20 mL) was added m-CPBA (with abs. 25% water, 1.69 g), and the mixture was stirred at room temperature for 24 hours. The resulting residue was added with ethyl acetate, aqueous sodium hydrogen carbonate solution, and aqueous sodium thiosulfate solution, and subjected to extraction. The organic layer was dried over anhydrous sodium sulfate, filtered off, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography to give the title compound (852 mg) as a white powder.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56946-65-7, 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[b]pyridine.
Reference:
Patent; Nippon Shinyaku Co., Ltd.; TSUJI, Takashi; SHIRAI, Masaaki; EP2891656; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem