Reference of 107867-51-6, Adding some certain compound to certain chemical reactions, such as: 107867-51-6, name is 5-(Trifluoromethyl)pyridine-2,3-diamine,molecular formula is C6H6F3N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 107867-51-6.
To the solution of I-B (499 mg, 1.51 mmol) in DMA (2.5 mL) at -5 C was added thionyl chloride (0.14 mL, 1.9 mmol). After stirring for 40 min at -5 C, a solution of 5- (trifluoromethyl)pyridine-2,3-diamine (295 mg, 1.66 mmol) in DMA (3 mL) was added to this reaction mixture. The reaction mixture was stirred at RT for 18 h. The reaction was quenched with water and extracted with DCM. Solid precipitated out from the organic phase, which was collected via filtration to afford N-(4-(l-((2-amino-5-(trifluoromethyl)pyridin-3- yl)carbamoyl)cyclobutyl)phenyl)-3-chlorobenzamide. MS (EI) m/z 489 [M+H]+.
According to the analysis of related databases, 107867-51-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Hua; ACHAB, Abdelghani; FRADERA, Xavier; HAN, Yongxin; LI, Derun; MCGOWAN, Meredeth, A.; SCIAMMETTA, Nunzio; SLOMAN, David, L.; YU, Wensheng; (98 pag.)WO2019/27855; (2019); A1;,
Pyridine – Wikipedia,
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