Extracurricular laboratory: Synthetic route of 626-64-2

The chemical industry reduces the impact on the environment during synthesis 626-64-2, I believe this compound will play a more active role in future production and life.

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 626-64-2 as follows., 626-64-2

Under nitrogen, 7-bromo-4-hydroxy-1-methyl-2-oxo -1,2-dihydro-quinoline-3-carboxylic acid methyl ester (1.00g, 3 . 2mmol), pyridin-4-ol (0.432g, 4 . 54mmol), N, N-dimethyl glycine (0.088g, 0 . 85mmol), cuprous iodide (0.082g, 0 . 43mmol), cesium carbonate (2.50g, 7 . 67mmol) and N, N-dimethylformamide (20 ml) were added in the flask. The reaction mixture is heated to 140 C for 12 hours. Cooling to room temperature, adding ice water (40 ml), using 1M pH=6 dilute hydrochloric acid is adjusted to, filtration, filters the filtrate, dry to give a white solid (1.05g, 100%).

The chemical industry reduces the impact on the environment during synthesis 626-64-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Zhuo, Yinglin; Wang, Xiaojun; Zhang, Yingjun; Wen, Liang; Wu, Shoutao; Yuan, Xiaofeng; (87 pag.)CN105384687; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem