With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, molecular weight is 224.08, as common compound, the synthetic route is as follows.72830-09-2
1.5 equiv of 2-chloromethyl pyridine hydrochloride, 1.5 equiv of K2CO3 and 0.15 equiv of KI were added to a magnetically stirred solution of 1.0 equiv of 5 or 12 (2.0mmol) in a mixture of acetone (15 mL) and EtOH (15 mL). The reaction mixture was stirred constantly at 45 C for about 4 h. When the reaction was finished, as monitored by HPLC-MS, enough water (50 mL) was added. Then the reaction mixture was extracted with DCM (20 mL ¡Á 3). The organic phase was combined and concentrated under reduced pressure to give crude compound 6 or 13. For a typical compound of 6, for example, 2-[(3,4-dimethoxypyridin-2-yl)methylthio]-6-nitro-5-(piperidin-1-yl)-1H-benzimidazole, the orange powder was obtained in 91% yield, with an HPLC purity >98%.
Statistics shows that 72830-09-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloromethyl-3,4-dimethoxypyridinium chloride.
Reference:
Article; Yan, Yu; Liu, Zijie; Zhang, Jianjun; Xu, Ruiming; Hu, Xiao; Liu, Gang; Bioorganic and Medicinal Chemistry Letters; vol. 21; 14; (2011); p. 4189 – 4192;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem