In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 65515-39-1, name is 2-Methoxy-4,6-dimethylnicotinonitrile, the common compound, a new synthetic route is introduced below. Quality Control of 2-Methoxy-4,6-dimethylnicotinonitrile
To a cooled (ice water bath) solution of 2-methoxy-4,6-dimethylnicotinonitrile (10 g, 61.7 mmol) in Et2O (200 mL) was added dropwise 1 M LiAIH4 in Et2O (123 mL, 123 mmol). The ice bath was removed and the reaction mixture was stirred at r.t. for 16 h. The reaction mixture was cooled in an ice water bath and quenched with a mininum amount of water (until no more hydrogen was generated). The reaction was filtered and the insoluble material was washed with 10: 1 DCM/MeOH. The combined organic filtrates were concentrated. The residue was purified via column chromatography (0 – 30% MeOH/DCM; 100 g-HP- silica gel column) to give (2-methoxy-4,6-dimethylpyridin-3- yl)methanamine (8.9 g) as a yellowish semi-solid.
The synthetic route of 65515-39-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; BRACKLEY, III, James A.; GRAVES, III, Alan Peterson; KNIGHT, Steven David; MCNULTY, Kenneth C.; NEWLANDER, Kenneth Allen; TIAN, Xinrong; (114 pag.)WO2017/2064; (2017); A1;,
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