The important role of (6-Bromopyridin-2-yl)methanamine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 188637-63-0, (6-Bromopyridin-2-yl)methanamine, other downstream synthetic routes, hurry up and to see.

Related Products of 188637-63-0 ,Some common heterocyclic compound, 188637-63-0, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 6-(2-cyanophenyl)-2-(3-fluorophenethylamino)nicotinic acid (582mg, 1.61 mmol) and 6-bromo-pyridin-2yl-methylamine (300mg, 1.61 mmol) in DMF was added CDI (261 mg, 1.61 mmol). The reaction mixture was stirred at r.t. for 2 h. The reaction mixture was purified on RP-HPLC to give N-((6-bromopyridin-2-yl)methyl)-6-(2- cyanophenyl)-2-(3-fluorophenethylamino)nicotinamide (700mg, 82%) LRMS (M+H+) m/z 530.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 188637-63-0, (6-Bromopyridin-2-yl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CYTOKINETICS, INCORPORATED; WO2008/16643; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem