Reference of 67058-77-9 , The common heterocyclic compound, 67058-77-9, name is 3-Nitro-1H-pyrrolo[2,3-c]pyridine, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 3 -nitro- 1H-pyrrolo [2,3 -c]pyridine (250 mg, 1.53 mmol) in DIVIF (5 mL) was added NaH (60% dispersion in mineral oil, 61 mg, 1.53 mmol). After stirred at 0 C for 10 mm, the mixture was added dimethylsulfate (193 mg, 1.53 mmol) dropwise. After stirred at 0 C for 3 hrs, the mixture was partitioned in a mixture of H20 (50 mL) and EA (50 mL). The aqueous phase was then extracted by EA (50 mL x 2). Organic phase was combined, dried over anhydrous Na2SO4, and evaporated in vacuum. The residue was washed with MeOH (5 mL) to afford 6-methyl- 3-nitro-6H-pyrrolo[2,3-c]pyridine (70 mg, 26%) as a yellow solid. ?H NIVIR (400 IVIHz, DMSO-d6):oe = 9.09 (s, 1H), 8.65 (s, 1H), 8.25 (dd, J 6.8, 1.2 Hz, 1H), 8.14 (d, J= 6.8 Hz, 1H), 4.26 (s, 3H). MS: m/z 178.0 (M+H).
The synthetic route of 67058-77-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem