Synthetic Route of 628691-93-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.628691-93-0, name is 2-Chloro-3-fluoroisonicotinic acid, molecular formula is C6H3ClFNO2, molecular weight is 175.55, as common compound, the synthetic route is as follows.
1.15.1. Step i: tert-butyl N-(2-chloro-3-fluoro-4-pyridyl)carbamate1002621 Diphenylphosphoryl azide (DPPA) (129 mmol) was added to a mixture of 2-chloro-3-fluoro- pyridine-4-carboxylic acid (85.7 mmol), Et3N (257 mmol) in 1:1 tert-BuOH/toluene (200 mL). The mixture was heated at 110C for 4 h. Mixture was diluted with H20 and extracted with DCM. The organic layer was dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (Si02, 100:0 to 80:20 DCM/EtOAc) to yield the desired product tert-butyl N-(2-chloro- 3 -fluoro-4-pyridyl)carbamate.
The chemical industry reduces the impact on the environment during synthesis 628691-93-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; MAMMOLITI, Oscar; BLANC, Javier; OR?ULIC, Mislav; RO?CIC, Maja; WO2015/110378; (2015); A1;,
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