Electric Literature of 824-52-2, Adding some certain compound to certain chemical reactions, such as: 824-52-2, name is 5-Methyl-1H-pyrrolo[2,3-b]pyridine,molecular formula is C8H8N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 824-52-2.
To 5-methyl-lH-pyrrolo[2,3-b]py?dine (IS, 2 00 g, 15 1 mmol) and aluminum trichloride (1 1 6 g, 87 2 mmol), nitromethane (63 1 mL, 1 16 mol) was added, followed by the addition of 2,6- difluoro-3-nitro-benzoyl chlonde (14, 3 22 g, 14 5 mmol) The reaction was placed in an oil bath at 45 0C and stirred for 3 days, then cooled to room temperature and 30 mL of methanol was added The reaction was then diluted with 200 mL of ethyl acetate and 100 mL each of water and IN hydrochloric acid, resulting in a precipitate that was collected to provide the desired compound (16, 2 761 g) Additonal compound was recovered from the organic layer, removing the solvent and purifying by silica gel column chromatography eluting with a gradient of 5 to 70% ethyl acetate in hexanes to provide another 126 mg of compound MS(ESI) [M+H+]+ = 317 9
According to the analysis of related databases, 824-52-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PLEXXIKON, INC.; IBRAHIM, Prabha, N.; SPEVAK, Wayne; CHO, Hanna; SHI, Songyuan; WU, Guoxian; WO2010/129567; (2010); A1;,
Pyridine – Wikipedia,
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