The origin of a common compound about 2-Chloro-3-methoxypyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52605-96-6, 2-Chloro-3-methoxypyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 52605-96-6, 2-Chloro-3-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H6ClNO, blongs to pyridine-derivatives compound. Computed Properties of C6H6ClNO

The 2-chloro-3-methoxypyridine (2) (13 g, 90.6 mmol), from Step I, was stirred with 3- equivalents of sodium methoxide (14.7 g, 271.8 mmol) in dimethylformamide (100 mL) at 10O0C until completion of the reaction. The reaction mixture was then quenched with water and extracted with dichloromethane. The combined extracts were washed with water, concentrated and distilled (74C; 5 mm Hg) to give the product, 2,3-dimethoxypyridine (3), as a clear oil (7 g; 29 % yield for two steps).1H NMR (300 MHz, CDCl3) delta 7.65 (dd, 1 H, Ji = 5.1 Hz, J2 = 1.5 Hz), 6.96(dd, 1 H, Ji = 7.5 Hz, J2 = 1.5 Hz), 6.76(dd, 1 H, J, = 5.1 Hz, J2 = 7.7 Hz), 3.95 (s, 3 H), 3.80 (s, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52605-96-6, 2-Chloro-3-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; BIONUMERIK PHARMACEUTICALS, INC.; WO2007/123995; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem