Electric Literature of 1254473-66-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1254473-66-9 as follows.
Acetyl chloride (41.99g, 534.88mmol) was added dropwise to a solution of 1E 1-(3,5-dichloropyridine-4-)ethanol(85.60g, 445.74mol), triethylamine (90.21g, 891.47mmol) in dichloromethane (1.5L) at 20C, and the mixture was stirredat 20C for 1 hour. When TLC showed the completion of the reaction, the solvent was evaporated under reduced pressureand the residue was purified by column chromatography to give the title compound (as a colorless oil, 57.10g, yield54.7%). 1H NMR (400 MHz, CHLOROFORM-d) ppm 8.44 (s, 2H), 6.25 (q, J=6.8 Hz, 1H), 2.09 (s, 3H), 1.63 (d, J=7.2Hz, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1254473-66-9, its application will become more common.
Reference:
Patent; Harbin Zhenbao Pharmaceutical Co., Ltd.; Medshine Discovery Inc.; CHEN, Shuhui; CHEN, Zhengxia; DAI, Meibi; XIE, Cheng; LI, Peng; ZHANG, Yang; LIANG, Guibai; WANG, Qiang; LIAO, Jiangpeng; SUN, Fei; HU, Guoping; LI, Jian; (166 pag.)EP3333157; (2018); A1;,
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