Electric Literature of 89510-90-7 , The common heterocyclic compound, 89510-90-7, name is 2-Chloro-5-fluoro-4-pyridinamine, molecular formula is C5H4ClFN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 2-chloro-5-fluoropyridin-4-amine (900mg, 6.41 mmol, 1 eq) in Morpholine (9ml_) was irradiated under microwave at 180C for 90min in 30ml_ vial. TLC analysis indicated formation of polar spot. Then, the reaction mixture was cooled to RT and poured on ice-waterto give a off white precipitate; which was purified by column chromatography (Silica gel 100-200mesh) using 40% EtOAc in petroleum ether as an eluent to give 5-fluoro-2- morpholinopyridin-4-amine (720mg, 57.14% yield) as an off-white solid. LC- MS: m/z 198.0 (M+ H).
The synthetic route of 89510-90-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
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