With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.94170-15-7, name is 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, molecular formula is C7H7NO2, molecular weight is 137.14, as common compound, the synthetic route is as follows.Application In Synthesis of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde
7-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)-2-((3S,4S)-4-isobutylpyrrolidin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (81.64 mg) was dissolved in DCM (4 mL).4-Aldehyde-1-methylpyridine-2(1H)-one (34.23 mg, 0.25 mmol) and sodium triacetoxyborohydride (110.2 mg, 0.52 mmol),Stir at room temperature overnight.TLC monitors the reaction completely,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Organic phase merger,Washed (2 × 5mL),Dry over anhydrous sodium sulfate,filter,concentrate,The crude product was separated by preparative thin layer chromatography (DCM:MeOH = 10:1)A white solid 7-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)-2-((3S,4S)-4-isobutyl-1-((1-methyl-) 2-oxo-1,2-dihydropyridin-4-yl)methyl)pyrrolidin-3-yl)pyrrolo[2,1-f][1,2,4]triazine-4(3H)-ketone(4.0 mg, yield: 3.7%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem