Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13269-19-7, name is 2-Nitropyridin-3-amine. A new synthetic method of this compound is introduced below., Quality Control of 2-Nitropyridin-3-amine
To a stirred suspension of 2-nitro-pyridin-3-ylamine (25.0 g, 179.7 mmol) andsodium acetate (15.5 g, 188.7 mmol) in acetic acid (150 mL), a solution of bromine (13.8 mL, 269.6 mmol) in acetic acid (50 ml) was added dropwise and the reaction mixture was stirred overnight. The acetic acid was removed under reduced pressure. The residue wascooled to 0C, neutralized with saturated sodium bicarbonate solution to adjust the pH to-7, and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. Theresidue was triturated with ethyl acetate to afford compound (34.4 g, 88% yield) as a
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Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DE LA ROSA, Martha Alicia; KAZMIERSKI, Wieslaw Mieczyslaw; (90 pag.)WO2019/3143; (2019); A1;,
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