133627-45-9, Adding a certain compound to certain chemical reactions, such as: 133627-45-9, 2-Chloro-4-methylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 133627-45-9, blongs to pyridine-derivatives compound.
Preparation process: 15 ml of acetone and 25 ml of acetic acid are added to a solution of 8 g of 2-chloro-3-amino-4-methylpyridine in 20 ml of dichloromethane.Add 6 ml of borane dimethyl sulfide solution at 0 C.It was then stirred at room temperature (r.t.) overnight.After the reaction was completed, a 25 wt% aqueous ammonia solution was added to adjust the pH to 8.After adding 50 ml of water, it was extracted three times with dichloromethane.The organic phase was collected and dried over anhydrous sodium sulfate,The crude product of product 1-3 was spin-dried and used directly in the next step (yellow oil).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,133627-45-9, its application will become more common.
Reference:
Patent; Nanjing Jianuolin Optoelectric Technology Co., Ltd.; Hang Xiaochun; Yin Junli; Liu Ruqing; (57 pag.)CN110615787; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem