Related Products of 1235036-15-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1235036-15-3 as follows.
To a solution of tert-butyl 3-bromo-6-chloropicolinate (5.92 g) in tetrahydrofuran (60mL)and water (30 mL) was added the crude Example 1.20.1 (4.44 g), 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamante (1.5 g), tris(dibenzylideneacetone)dipalladium(O) (927 mg) and20 K3P04(22 g). The mixture was stirred at reflux overnight, cooled, diluted with ethyl acetate (800 mL)25and washed with water and brine. The organic layer was dried over sodium sulfate, filtered, andconcentrated. The residue was purified by flash chromatography, eluting with 20% ethyl acetate inheptane followed by 5% methanol in dichloromethane, to give the title compound. MS (ESI) m/e531.1 (M+Ht.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1235036-15-3, its application will become more common.
Reference:
Patent; ABBVIE INC.; BOGHAERT, Erwin, R.; SOUERS, Andrew, J.; PHILLIPS, Andrew, C.; JUDD, Andrew, S.; BRUNCKO, Milan; (717 pag.)WO2017/214282; (2017); A1;,
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