Related Products of 7477-10-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7477-10-3, name is 6-Chloro-5-nitronicotinic acid, molecular formula is C6H3ClN2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
6-(Cyclohexylamino)-5-nitronicotinic acid (57) To a solution of intermediate 56 (10.1 g, 49.9 mmol) and triethylamine (14.6 mL, 125.0 mmol) in acetonitrile (130 mL) and DMSO (25 mL) was added cyclohexylamine (13.7 mL, 100 mmol). The reaction mixture was heated to reflux (90 C.) under a nitrogen atmosphere for 20 h. The reaction mixture was cooled to rt and concentrated on a rotary evaporator and the residue was dissolved in 800 mL 1N sodium hydroxide solution. This solution was washed with dichloromethane (3*75 mL) and then made acidic (pH=5) with concentrated hydrochloric acid. The precipitated product was collected by vacuum filtration and washed sparingly with cold water to afford the HCl salt of intermediate 57 as a yellow solid (9.8 g, 65%). ESI-MS m/e 266.2 (M+1).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7477-10-3, 6-Chloro-5-nitronicotinic acid.
Reference:
Patent; Priestley, Eldon Scott; Decicco, Carl P.; Hudyma, Thomas W.; Zheng, Xiaofan; US2003/134853; (2003); A1;,
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