Reference of 1214326-89-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1214326-89-2, name is 3-Bromo-5-fluoropyridin-4-amine. A new synthetic method of this compound is introduced below.
A mixture of 4-bromo-2-fluoro-pyridin- 3-amine (2.29 g, 12.0 mmol) and potassium ethoxymethanedithioate (3.85 g, 24.0 mmol) in NMP (12 mL) was heated in a microwave at 170 C for 45 min when the reaction mixture turned dark red. The reaction mixture was cooled to 23 C, poured into AcOH and water (10% v/v, 200 mL). The resulting precipitate was collected by filtration to give the title compound (2.94 g, 99% yield) as yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 8.72 (s, 1H), 8.60 (s, 1H). LCMS m/z: 249 [M+H+].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1214326-89-2, 3-Bromo-5-fluoropyridin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; GANCIA, Emanuela; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven, R.; SAJAD, Mohammed; TSUI, Vickie, H.; WILLIAMS, Karen; ZHANG, Birong; WO2015/91584; (2015); A1;,
Pyridine – Wikipedia,
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