As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1796-84-5, name is 4-Ethoxy-3-nitropyridine, molecular formula is C7H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1796-84-5
Into a 1 L flask containing 250 mL of dry THF cooled to -780C was condensed NH3 (100-150 mL). Neat t-BuOK (182 mmol, 20.5 g) was added to the THF which completely dissolved after 10 min of vigorous stirring. In a separate 500 mL flask, 10OmL of dry THF containing 4-(ethyloxy)-3-nitropyridine (12.3 g, 72.9 mmol) was cooled to 0C. To this solution was added t-BuOOH (80.2 mmole, 14 mL). The t-BuOOH/THF solution was then added to the -780C ammonia solution over 20 min via dropping funnel. The reaction solution was allowed to warm to – 40C and then stirred at this temperature for 1 h. The reaction was quenched with saturated NH4CI solution (20 mL) and the cooling bath removed. The reaction solution was allowed to stir overnight at RT. The precipitate was filtered and dried under vacuum using a toluene azeotrope: LCMS: m/z 185 [M+H]+.
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Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/113837; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem