Application of 824-52-2, Adding some certain compound to certain chemical reactions, such as: 824-52-2, name is 5-Methyl-1H-pyrrolo[2,3-b]pyridine,molecular formula is C8H8N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 824-52-2.
Example 22; 5-methyl-1-f4-f1-f6-methylpyridin-3-vh-4-fpyridin-2-ylV1H-imidazol-2-yl^phenyl>-1H- Dyrrolof 2.3-blPVridine; A mixture of 2-(2-(4-iodopheny1)-1-(6-methylpyridin-3-yi)-1H-imidazol-4-yl)pyridine(200 mg, 0.46 mmol), 5-methyl-1H-pyrrolo[2,3-b]pyridi?e (62 mg, 0.46 mmol), CuI (4 mg, 0.022 mmol), K3PO4 (210 mg, 1.0 mmol), and fra?s-N.N’-dimethyl-cyclohexa?e-i^-diamine (12 mg, 0.05 mmol) in p-dioxane (1 mL) was heated by microwave at 150 0C for 1.5h. Additional 5-methyl-7-azai?dole (62 mg, 0.46 mmol), CuI (4 mg, 0.022 mmol), and diamine (12 mg) were added and the mixture heated by microwave at 1600C for 1h. The mixture was filtered, concentrated and the residue purified by SGC (1% and 2% MeOH in DCM, 0.5% NH4OH) giving a solid which was triturated with ether and dried. Yield 18 mg. 1H NMR (CDCI3) .68.57 (m, 2H), 8.18-8.12 (m, 2H), 7.90 (br, 1H), 7.82-7.73 (m, 4H), 7.59 (m, 2H), 7.51-7.47 (m, 2H)1 7.23-7.18 (m, 2H), 6.54 (d, 1H1 J = 3.3 Hz), 2.62 (s, 3H), 2.43 (s, 3H). A second compound appearing to contain two methyl resonances was present in about 10 % amount (s, 2.69), (s, 2.34). MS (ES+) m/e 443 (MH+). The material was homogeneous by HPLCMS: 6.85 min, m/e 443 (MH+). IC50 = 12.1 nM
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 824-52-2, 5-Methyl-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/4117; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem