Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4684-94-0, name is 6-Chloropicolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 6-Chloropicolinic acid
INTERMEDIATE 456-Chloropyridine-2-carboxamide 6-Chloropyridine-2-carboxylic acid (1.20 g, 7.62 mmol) and ammonium chloride (0.81 g, 15.2 mmol) were dissolved in DMF (20 mL) and DIPEA (5.31 mL, 30.5 mmol), HONB (2.05 g, 11.4 mmol) and HBTU (4.33 g, 11.4 mmol) were added. The reaction mixture was stirred for 1 h and the solvents were removed in vacuo. The residue was partitioned between DCM (50 mL) and 1 M aq HC1 (50 mL) and the aq fraction was extracted with DCM (2 x 25 mL). The combined organic fractions were washed with sat aq NaHCC>3 (50 mL), brine (50 mL), dried (MgS04) and concentrated in vacuo. The residue was recrystallised from MeOH / water to give the title compound (1.12 g, 94%) as a white solid. LCMS (ES+): 157.4 [MH]+.
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Reference:
Patent; PROXIMAGEN LTD; BROWN, Giles; HIGGINBOTTOM, Michael; STEWART, Alison; PATIENT, Lee; CARLEY, Allison; SIMPSON, Iain; SAVORY, Edward Daniel; OLIVER, Kathryn; COLE, Andrew, Graham; WO2012/49277; (2012); A1;,
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