Adding a certain compound to certain chemical reactions, such as: 6318-51-0, (4-Chlorophenyl)(pyridin-2-yl)methanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C12H8ClNO, blongs to pyridine-derivatives compound. COA of Formula: C12H8ClNO
4-chlorophenylpyridyl ketone (43.5mg, 0.2mmol), dibromantin (57.2mg, 0.2mmol) and Pd (OAc) 2 (4.5mg, 0.02mmol), 2mL of dichloroethane, 90C The reaction was carried out for 12 hours and purified by thin layer chromatography to obtain 30.2 mg of 2-bromo-4-chlorophenylpyridylmethanone, with a yield of 50.9%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6318-51-0, (4-Chlorophenyl)(pyridin-2-yl)methanone, and friends who are interested can also refer to it.
Reference:
Patent; China Three Gorges University; Liu Qixing; Chen Yongsheng; Zhang Yin; Chen Danyi; Wen Simiaomiao; Zhao Rongrong; Liu Yiheng; Zhou Haifeng; (14 pag.)CN110563641; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem