Synthetic Route of 64951-08-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below.
ER-879054-00: As depicted in Scheme 47 above, ER-824188-00 (20.0 mg, 0.0538 mmol) was dissolved in NMP (0.500 mL). Added Imidazo[l,2-a]pyridine-2- carboxylic acid (49.9 mg, 0.308 mmol). Added N,N,N’,N’-Tetramethyl-O-(7- azabenzotriazol-l-yl)uranium hexafluorophosphate (51.2 mg, 0.134 mmol) in NMP (0.500 mL). The reaction was heated at 1000C for 5 minutes in the microwave. The reaction was not complete so it was stirred at room temperature overnight. The mixture was filtered. Purification by LC/MS followed by evaporation using the genevac provided ER-879054-00 (8.6 mg, 31%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; SPYVEE, Mark; CHEN, Qian; CARLSON, Eric; KUSANO, Kuzutomi; WO2011/11494; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem