Synthetic Route of 71777-70-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71777-70-3, name is Ethyl 4-ethoxypicolinate, molecular formula is C10H13NO3, molecular weight is 195.22, as common compound, the synthetic route is as follows.
To a solution of ethyl 4-ethoxypicolinate 198 (1 .6 g, 8.2 mmol) in concentrated H2SO4 (80 mL) was added NBS (2.7 g, 14.8 mmol). The reaction was stirred at room temperature overnight then quenched by addition of saturated aqueous NaHCCb (150 mL). The aqueous layer was extracted with DCM (3 x 130 mL) and the combined organic layers dried ( a2S04) and concentrated to give the title compound as a yellow solid (2.0 g, 91 %). 1H NMR (400 MHz, CDCI3) delta 8.67 (s, 1 H), 7.63 (s, 1 H), 4.94-4.40 (m, 2H), 4.29-4.23 (m, 2H), 1 .54-1 .51 (0853) (m, 3H), 1 .46-1 .42 (m, 3H); LCMS-C: RT 2.59 min; m/z 274.0, 276.0 [M+H]+
Statistics shows that 71777-70-3 is playing an increasingly important role. we look forward to future research findings about Ethyl 4-ethoxypicolinate.
Reference:
Patent; CTXT PTY LTD; BERGMAN, Ylva Elisabet; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; CAMERINO, Michelle Ang; WALKER, Scott Raymond; LAGIAKOS, H. Rachel; FEUTRILL, John; STEVENSON, Graeme Irvine; STUPPLE, Paul Anthony; (222 pag.)WO2016/34673; (2016); A1;,
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