A common compound: 5470-70-2, name is Methyl 6-methylnicotinate,molecular formula is C8H9NO2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 5470-70-2
[Step 1] Synthesis of methyl 6-bromomethylnicotinate methyl 6-methylnicotinate (1 g) was dissolved in carbon tetrachloride (100 ml), and N-bromosuccinimide (1.3 g) was added. The mixture was heated under reflux in an argon atmosphere for 8 hours, and allowed to cool. The precipitated crystals were removed by filtration, and the solvent was evaporated from the filtrate under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/methylene chloride=1:3) to obtain the title compound (540 mg, 35%). m.p.: 75.2-76.3 C. IR spectrum (KBr tab.) nucm-1: 1728, 1713, 1595, 1435, 1286, 1124, 1103. NMR spectrum (*DMSO-d6) delta ppm: 9.05 (1H, s), 8.34-8.30 (1H, m), 7.71 (1H, d, J=7.9 Hz), 4.77 (2H, s), 3.89 (3H, s).
With the rapid development of chemical substances, we look forward to future research findings about 5470-70-2.
Reference:
Patent; Mochida Pharmaceutical Co., Ltd.; US6018046; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem