1990-90-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1990-90-5, name is 3-Methylpyridin-4-amine, molecular formula is C6H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a suspension of the imino chloride [(500MG,] 1. [42MMOL)] in dioxane [(5ML)] was added Pd2 (dba) 3 (65mg, 0. [07MMOL)] followed by BINAP (66mg, [0.] [1] [LMMOL),] 4-amino-3-picoline (230mg, 2. [13MMOL)] and NaO’Bu (273mg, 2. [84MMOL).] The reaction mixture was heated to [90C] for 15h. The reaction mixture was cooled to r. t. and filtered through Celite and the crude 219002029440 material purified by flash column chromatography to give (152 mg, 24% yield) as a cream colored solid. ESMS: 440 [(M+).]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1990-90-5, 3-Methylpyridin-4-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SCIOS INC.; WO2004/24159; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem